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Taking the capsules with meals may help. There's some concern that fish oil at higher doses (e.g., more than 3 grams daily) might blunt the immune response. That could be a problem for elderly individuals and those with suppressed b2b immune function related to medications or diseases such as HIV infection. Doses greater than 3 grams b2b daily can thin the blood. Combining fish-oil supplements with other blood-thinning drugs or supplements merits caution due b2b to the potential risk of excessive bleeding. Such drugs include aspirin, NSAIDs (e.g., ibuprofen, naproxen), clopidogrel (Plavix), dalteparin (Fragmin), enoxaparin (Lovenox), and warfarin (Coumadin). Supplements include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, turmeric, willow, flaxseed oil, phosphatidylserine, policosanol and high-dose vitamin E. One sign of bleeding is unusual bruising.
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