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No consistent effect was found among the 24 randomized trials (among ldl cholesterol 59 available studies) of fibrinogen with data on at least 15 subjects in parallel trials and 10 subjects in crossover trials who consumed omega-3 fatty acids. Nor ldl cholesterol was a consistent effect found among the 19 randomized trials of factor VII with at least 15 subjects in parallel trials and 10 subjects in crossover trials who consumed omega-3 fatty acids, or the five available randomized trials of factor VIII. The nine available randomized trials of vWF mostly found a small, non-significant decrease in level ldl cholesterol with omega-3 fatty acid consumption. The results among the 11 analyzed studies of platelet aggregation were heterogeneous depending on aggregating agent, dose of agent, and measurement metric used, however, in most studies no effect was found with omega-3 fatty acid intake.
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