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The most persuasive evidence of cardioprotection comes from randomized trials with clinical cardiovascular outcomes. (4) To date, more than 10 such trials of the use of omega-3 fatty acids have been conducted in patients with previous cardiovascular disease, but only one trial was conducted in persons without preexisting cardiovascular disease. Many of the trials, including the only primary prevention trial, omegafatty acid flax fish oil newsletter had a small sample size and, accordingly, were underpowered. The most salient omegafatty acid flax fish oil newsletter of the available trials are the Diet and Reinfarction Trial (DART) (5) and the GISSI Prevenzione trial. (6) In DART, omegafatty acid flax fish oil newsletter which enrolled 2,033 men with a previous myocardial infarction, those who received advice to increase their intake of fatty fish had a 29 percent reduced risk of total mortality over two years. However, during a follow-up study of DART participants, the early reduction in risk observed in those assigned to the fish advice group was followed by increased risk over the course of the next three to nine years.
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