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Results: Sixteen studies, described healthy diet in 16 published journal articles, were found to investigate nine of 23 potential questions. Question-specific qualitative syntheses of the evidence were derived. Greater interpretative emphasis was placed on evidence from randomized controlled trials (RCTs) and other designs that were both prospective and healthy diet controlled. Too little, or flawed, available evidence precluded meta-analysis for each question. Conclusions: Based on the healthy diet studies identified by this review, clinical research has only scratched the surface with respect to understanding the possible utility of the intake of omega-3 fatty acids as a primary or secondary prevention in eye health. Moreover, seen from the point of view of clinical research's typical, linear arc—which moves from basic science to observational research to RCTs, and culminating in the systematic review/meta-analysis of the observations obtained by these primary studies—there is a paucity of solid observational research with which to construct an experimental framework affording the meaningful conduct of RCTs.
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