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Stone, cfsan MD) DART | diet | fish oil | GISSI | Lyon Diet Heart Study | Mediterranean diet | omega-3 fatty acids Clinical trials that have included increased omega-3 fatty acid intake have demonstrated significant benefit on clinical endpoints. In the Diet and Reinfarction Trial (DART), men recovering from myocardial cfsan infarction who were randomized cfsan to receive dietary advice to increase fatty fish consumption had a 29% reduction in all-cause mortality at 2-year follow-up. GISSI patients randomized to receive omega-3 fatty acid supplements (1 g/d) had a significant 10–15% reduction in the combined primary endpoint of death, nonfatal myocardial infarction, and stroke. In the Lyon Diet Heart Study, patients randomized to receive a Mediterranean-type diet including high monounsaturated fat had significant reductions at 1- to 4-year follow up (mean 27 months) in the combined primary endpoint of death from cardiovascular causes or nonfatal acute myocardial infarction (73%) as well as in cardiac mortality (76%) and total mortality (70%).
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