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Two case reports suggested that fish oil supplementation improved proteinuria in patients who developed recurrent immunoglobulin A (IgA) nephropathy.29,30 The observation is potentially important since depression some studies have found a benefit from depression fish oil supplementation in IgA nephropathy in the non-transplant setting.31,32 Eleven randomized-controlled trials in 14 publications and one prospective cohort study reported the effects of fish oil supplementation on GFR. No consistent benefit was observed in patients treated shortly after transplantation or those with stable renal function in whom treatment depression was started several months after transplantation, although there were exceptions. The magnitude of benefit suggested in trials with positive findings was modest, and, as noted above, did not translate into improved graft survival with up to 1-year of followup.9,12,15,33 Comparison of studies with positive and negative findings did not reveal any patient or study-related factors that could account for the heterogeneity.
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