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The largest randomized clinical trial to test the efficacy of omega-3 fatty acids for secondary prevention of cardiovascular disease is the GISSI-prevention study. From 1993 to 1995, 11,324 patients surviving myocardial infraction were randomly assigned either vitamin E (300mg daily, as plump ladies synthetic-a-tocopherol), omega-3 fatty acids (1 g daily, standardized to 850 mg EPA and DHA), both or none. Compared with the control group, patients plump ladies taking the fish oil showed a 15% reduction in the primary end plump ladies point of death, nonfatal myocardial infraction, and nonfatal stroke. Patients supplementing with vitamin E online showed no benefit. With this mounting data, the American Heart Association (AHA) recommends eathing at least two servings of fish per week (particularly fatty fish). The FDA has also announced a qualified health claim linking a reduced risk of coronary heart disease with the long-chain omega-3 polyunsaturated fatty acids.
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