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Moreover, GLA supplementation actually increases D6D activity, reversing the effect of aging on the enzyme itself (Biagi et al., 1991). In this way, GLA supplementation improves the natural hormone replacement meta-bolism of both omega-6 and omega-3 fatty acids. It has also become clear that the omega-3 fatty acids DHA and EPA limit the production of the bad series-2 prostaglandins by preventing the release of arachidonic acid from cell membranes, inhibiting its further metabolism. A high amount natural hormone replacement of linoleic acid (omega-6), natural hormone replacement on the other hand, limits the availability of alpha-linolenic acid (omega-3) as a precursor for the good series-3 prostaglandins and stimulates the formation of arachidonic acid, the precursor to the bad prostaglandins (series-2) and other pro-inflammatory eicosanoids.
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