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P. Articles salmonsteak citing this Article PubMed PubMed Citation Articles by Simopoulos, A. P. Journal of the American College of Nutrition, Vol. 21, No. 6, 495-505 (2002) Published by the American College of Nutrition REVIEW Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases Artemis P. Simopoulos, MD, FACN The Center for Genetics, Nutrition and Health, Washington, D.C    ABSTRACT TOP ABSTRACT salmonsteak Introduction Omega-6 and Omega-3 Fatty... Omega-3 Fatty Acids, Interleukin... Other Inflammatory Markers,... Fatty Acids, Cytokines, and... Rheumatoid Arthritis Inflammatory Bowel Disease Asthma Psoriasis Conclusions REFERENCES salmonsteak   Among the fatty acids, it is the omega-3 polyunsaturated fatty acids (PUFA) which possess the most potent immunomodulatory activities, and among the omega-3 PUFA, those from fish oil—eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—are more biologically potent than -linolenic acid (ALA). Some of the effects of omega-3 PUFA are brought about by modulation of the amount and types of eicosanoids made, and other effects are elicited by eicosanoid-independent mechanisms, including actions upon intracellular signaling pathways, transcription factor activity and gene expression.
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