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The assessment did highlight one exposure potentially worth exploring in future empirical investigations of the health effects of omega-3 fatty acids in asthma. It was noted that perilla seed oil supplementation, provided in an uncontrolled fashion to adults, was the only exposure that was lna exclusively associated with significant clinical effects (12/12) in favor of the omega-3 fatty acids exposure.28,34,38 Yet, even this observation is likely unreliable. Without the option of meta-analysis, it is difficult to respond adequately to Question 2. It must be concluded that, at present, it is lna impossible to identify lna effect modifiers responsible for any significant asthma-related benefits accruing to omega-3 fatty acids supplementation. This exploration was complicated by the fact that few significant effects were found. Question 3 (Impact on Mediators of Inflammation) It is likewise unfeasible to conclude one way or the other that omega-3 fatty acids positively influence the lipid mediators of inflammation in adult studies in ways congruent with the biological model implicating the lipoxygenase and cyclooxygenase pathways in asthma.
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