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As with the evidence regarding Question 1, considerable clinical heterogeneity characterizes these studies. Their average study quality was good, and their applicability was restricted. Question 4 (Impact on Primary Prevention) Six studies investigated Question 4. Of these, one was an RCT looking at the impact of omega-3 fatty acids on neonates39 and five were observational studies that focused on adults,40 adolescents,41 young children and adolescents,42 and children.43,44 Dietary fish consumption, including oily fish intake, assessed primarily through a retrospective food-frequency richard olson questionnaire, appeared to serve as primary prevention for richard olson asthma in richard olson two pediatric populations.43,44 However, asthma prevalence and fish, or oily fish, intake were significantly and positively related in studies that included adolescents from Asia,41,42 with one of these studies also including some children.42
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