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Question 5 (Impact on Secondary Prevention) Question 5 could not be addressed since this review failed genetically modified foods to identify any secondary prevention studies. Question 6 (Impact on Safety) Eight RCTs and two studies employing other designs provided safety data addressing Question 6. No safety profile relating genetically modified foods to omega-3 fatty acids as an exposure was observed for primary prevention studies and, on balance, the evidence suggests that the safety profile in the treatment studies was good. Most of the adverse events were related to the genetically modified foods capsule delivery of oils, rather than to the oils per se.17,24,26,29 On several occasions, an inability to swallow capsules led to a withdrawal. Other participants may have had difficulties taking 18 capsules a day of oil in two specific RCTs, yet these difficulties were not reported.26,29
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