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Discordant results were noted among the studies measuring improvement in renal function. eft There were no clear patient- or study-related characteristics to account for the heterogeneity, and any functional improvement did not translate into other clinically important outcomes, such as improved graft eft survival. A meta-analysis of rejection episodes in kidney transplantation found no statistically significant benefit on either early (<6 months post transplant) or late rejection with supplementation during followup of up to 1 year (relative risk = 0.91; 95% CI = 0.74, 1.10). A meta-analysis of graft survival in kidney transplantation found no significant benefit eft from fish oil supplementation (relative risk = 1.00; 95% CI = 0.96, 1.05). No clinically important interactions were observed between fish oil supplementation and the dose or trough-levels of cyclosporin A.
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