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Dose-response studies demonstrated that DHA is more effective than EPA, and that diets with combinations of these two omega-3 fatty acids are synergistic [6,8688]. Kremer in 1985 [89] carried out a pilot study in 17 patients with rheumatoid arthritis who consumed 1.8 g detox EPA and 0.9 g DHA. This was a detox double-blind, controlled, randomized trial of 12 weeks duration with a follow up evaluation one to two months after the diets and supplements were discontinued. Standard clinical measures of arthritis activity were performed at baseline and detox after 4, 8 and 12 weeks and at follow up. The results showed a significant difference in morning stiffness between the two groups at the time of the 12-week evaluation, which represented a worsening in the control group, while the fish oil supplemented group remained unchanged.
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