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Plasma phospholipid EPA correlated very closely with peripheral blood mononuclear cell EPA levels media room (r = 0.97). Thus, they measure non-fasting EPA level, mononuclear cell EPA level and the degree of inhibition in the synthesis of the inflammatory cytokines IL-1ß and TNF ex vivo in human volunteers given diets fortified with omega-3 fatty acids [49]. They noted substantial inhibition of IL-1ß and TNF when the mononuclear cell level of EPA was equal media room to or greater than 1.5% of total cell phospholipid fatty acids and correlated with a plasma phospholipid EPA level equal to or greater than 3.2%. In their media room clinic, patients achieving the target EPA level tended to have higher discontinuation rates of NSAIDs [92].
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