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Broughton et al. [35] studied the effect of omega-3 fatty acids at a ratio of omega-6:omega-3 of 10:1 to 5:1 in n 3 an asthmatic population in ameliorating methacholine-induced respiratory distress. With low omega-3 ingestion, methacholine-induced respiratory distress increased. With high omega-3 fatty acid ingestion, alterations in urinary 5-series leukotriene n 3 excretion predicted treatment efficacy and a dose change in >40% of the test subjects (responders) whereas the non-responders had a further loss in respiratory capacity. A urinary ratio of 4-series to 5-series of <1 induced by omega-3 fatty acid ingestion may predict respiratory benefit. Psoriasis TOP ABSTRACT Introduction Omega-6 and n 3 Omega-3 Fatty... Omega-3 Fatty Acids, Interleukin... Other Inflammatory Markers,... Fatty Acids, Cytokines, and... Rheumatoid Arthritis Inflammatory Bowel Disease Asthma Psoriasis Conclusions REFERENCES The recognition that AA metabolism is altered in psoriasis prompted attempts to inhibit the generation of proinflammatory lipoxygenase products, LTB4 and 12-hydroxyeicosatetraenoic acid (12-HETE), which are markedly elevated in the psoriatic lesions [100].
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