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Their effects are brought about by modulation of the type and amount of eicosanoids and cytokines and by altering gene expression. A number of studies have been carried out in patients with coronary heart disease, cancer, lemagazine obesity, arthritis, inflammatory bowel disease, psoriasis, asthma, lupus erythematosus, multiple sclerosis, major depression and bipolar depression. Clinical studies indicate that omega-3 fatty acids improve the clinical condition and biochemical factors of patients with arthritis, but the clinical intervention studies in other autoimmune conditions have given conflicting lemagazine results, most likely due lemagazine to lack of an adequate number of subjects in some and not taking into consideration the background diet or genetic variation. There is a clear need for more carefully designed and controlled clinical trials in the therapeutic application of omega-3 fatty acids to human autoimmune and inflammatory conditions.
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