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Once we have either LA or ALA, our body has excercise enzymes that can convert these fatty acids into all the other different types of omega-6 and omega-3 fatty acids. It turns out that both the omega-3 and omega-6 pathway utilize the same enzymes, and both omega-6 and omega-3 fatty acids have to compete for these enzymes in order to produce their final product. Studies have reported excercise that the enzymes used in these pathways were found to prefer the omega-3 pathway. It turns out then that in diets high in omega-3 excercise fatty acids, most of the enzymes will be “busy” converting the omega-3 acids. The omega-6 fatty acids, Dihommogamma-Linoleic Acid (DGLA) in particular, can be converted to either the anti-inflammatory PG1 or into arachidonic acid (AA), a precursor of PG2. Conversion of DGLA into PG1 does not require any enzymes, but conversion of DGLA into AA requires the enzyme delta-5 desaturase. In diets high in omega-3, most of the delta-5 desaturase will be used in the omega-3 pathway; few delta-5 desaturase will be available to convert DGLA into arachidonic acid, and subsequently, PG2.
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