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Significant bias that may invalidate the results. A study with serious errors in design, analysis, or reporting. Applicability In this report, the focus is on the U.S. population. We categorized studies based on the study eligibility criteria into four populations: generally healthy people, people with CVD, people with diabetes, and people with dyslipidemia. A study could be categorized into multiple populations, as appropriate. We further categorized studies within a target population into one of three levels of applicability:8 fibrocystic I—Sample is representative of the target population. It should fibrocystic be sufficiently fibrocystic large to cover both sexes, a wide age range, and other important features of the target population including baseline dietary intake broadly similar to that of the U.S. population. II—Sample is representative of a relevant sub-group of the target population, but not the entire population. III—Sample is representative of a narrow subgroup of subjects only, and is not applicable to other subgroups.
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