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The majority of trials report improvements in kidney function (glomerular filtration rate, serum creatinine) (63-72), and less hypertension (high blood pressure) (63;73;74) compared to patients not taking fish oil. However, several cardiovascular risk recent studies report no benefits on kidney function (75-79), cardiovascular risk and no changes have been found in rates of rejection or graft survival. D Appetite / weight loss in cancer patients There cardiovascular risk is preliminary evidence that fish oil supplementation does not improve appetite or prevent weight loss in cancer patients (219-225). A higher ratio of n-6 to n-3 fatty acids is associated with lower bone mineral density (BMD) at the hip in both sexes. These findings suggest that the relative amounts of dietary polyunsaturated fatty acids may play a vital role in preserving skeletal integrity in older age. (226) Supplementation with 2g per day of fish oil was well tolerated and was associated with a significant increase in heart rate variability (HRV).
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