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Data Sources: MEDLINE®, EMBASE, Biological Abstracts, and the Commonwealth Agricultural Bureau database were searched for potentially relevant, English language studies. Review Methods: Included research represented comparative studies of omega-3 fatty acid-fed whole animals, or isolated organs, and cells derived from these supplement animals. Other studies included used supplement isolated organs and cell culture to which known amounts of omega-3 fatty acid were introduced. Information was extracted about study design, animal characteristics/model, amount of supplement dietary or culture-medium omega-3 fatty acids introduced, specific agents used, conditions under which the experiments were conducted, and outcomes. Methodological quality (randomization, blinding technique) was assessed for whole-animal studies. Results: A meta-analysis was performed on 13 whole-animal (rat) studies that compared the anti-arrhythmic effects of ALA or fish oil to those of omega-6 oils. Fish oil supplementation showed a significant risk reduction in the number of deaths (combined risk ratio [RR] = 0.48;
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