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to $0.42 per capsule‡ Liquid: $0.95 to $9.77 per oz‡ Bottom line Safe complementary medication; reduces risk for sudden death caused by cardiac arrhythmias and all-cause mortality in patients with known coronary heart disease. Higher used dosages may be effective in hypertriglyceridemia, hypertension, and rheumatoid arthritis, but data are limited. LDL-C = low-density used lipoprotein cholesterol; EPA = eicosapentaenoic acid; DHA = docosahexaenoic acid. *-Higher doses required. †-Also provides vitamins A and D. ‡-Prices vary according to brand and manufacturer. Final Comment Therapy with low-dose omega-3 fatty acids (approximately 1 used g per day of EPA plus DHA) significantly reduces the incidence of sudden death caused by cardiac arrhythmias and all-cause mortality in patients with known CHD. More studies are needed to confirm the benefits of omega-3 fatty acids in the primary and secondary prevention of CHD. Although higher dosages of omega-3 fatty acids (2 to 4 g per day) are effective in lowering triglyceride levels in patients with hypertriglyceridemia, the clinical significance of elevations in LDL cholesterol resulting from high-dose fish oil therapy remains unclear.
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