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Stable (non-radioactive) isotopes of oxygen or hydrogen are given to the subject as a drink of special water. The subject collects a saliva or urine sample before the drink and again a few hours later. Careful analysis can with then measure how the special isotopically-labelled water has been diluted in the body. In this way it is possible to calculate the total amount of water in the subject and from this how much with lean tissue and how much fat there is in the body. A scanning technique can also be used to measure the composition of the body. Dual with energy X-ray absorptiometry (DXA) was originally developed to measure bone and it is widely used to diagnose osteoporosis, but it can also estimate the amount of fat and lean tissue. Since there are hundreds of these machines in hospitals and clinics throughout the country this is becoming a very popular way to measure body composition.
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