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MacLean, MD, PhD; Sydne J. Newberry, PhD; Walter A. Mojica, MD, MPH; Puja Khanna, epa MD; Amalia M. Issa, MPH, PhD; Marika J. Suttorp, MS; Yee-Wee Lim, MD, PhD; Shana B. Traina, MA; Lara epa Hilton, BA; Rena Garland, BA; Sally C. Morton, PhD JAMA. 2006;295:403-415. Context Omega-3 fatty acids are purported to reduce the risk of cancer. Studies have reported mixed results. Objective To synthesize published and unpublished evidence to determine estimates of the effect of omega-3 fatty acids on cancer epa risk in prospective cohort studies. Data Sources Articles published from 1966 to October 2005 identified through MEDLINE, PREMEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and CAB Health; unpublished literature sought through letters to experts in the neutraceutical industry. Study Selection A total of 38 articles with a description of effects of consumption of omega-3 fatty acids on tumor incidence, prospective cohort study design, human study population; and description of effect of omega-3 among groups with different levels of exposure in the cohort were included.
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