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Perhaps the greatest risk of fish oil omega-3 supplementation is heavy metal poisoning by the body's accumulation of traces of heavy metals heavy metal poisoning, in particular; mercury, lead, nickel, arsenic and cadmium and other contaminants (PCBs, furans, dioxins), which may be found in less refined fish prostaglandins oil supplements. For these reasons, the FDA recommends that total dietary intake of omega-3 fatty acids be limited to 3 grams per day, of which no more than 2 grams per day are prostaglandins from nutritional supplements.[2] However, many nutritionists recommend more than this, pointing out that the few studies used by the FDA do not show conclusively that high doses of omega-3 fatty acids are harmful in any way. More research on this aspect of omega-3 is being done. The solution to safe supplementation with fish oil is to ensure that the oil is pure.
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