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In this study, 11 324 patients who had experienced a myocardial infarction were assigned to supplemental interventions following the introduction of a Mediterranean-type diet (which included moderate fish consumption), as well as aggressive treatment with various pharmaceutical agents for cardiovascular care. About half the patients received an encapsulated omega-3 fish oil supplementation (providing 850-882 mg/day EPA plus flax seeds DHA). Over the subsequent interval (3.5 years), the individuals flax seeds who received omega-3 supplements were flax seeds found to exhibit a significant reduction in overall cardiovascular deaths and a reduction in sudden cardiac death of about 45%. Vitamin E (-tocopherol) supplementation, which was also studied in this trial, was without significant effect in this regard.
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