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This intake is about 4 times that of current North American consumption transparency rates. Epidemiological data from the Multiple Risk Factor Intervention Trial in the United States have indicated that progressively higher intakes of the fish-derived omega-3 fatty acids (up to about 665 mg/day) over 10.5 years were associated with a progressive reduction in mortality related to coronary heart disease, as well as total mortality with no associated increase in total cancer-related mortality.34 A transparency recent review of the existing evidence indicated that an increase in the consumption of transparency fish may contribute to lower colorectal cancer and breast cancer risks.35 In summary, there is evidence for the beneficial effect of regular fish consumption (up to 2-3 times/week) both in healthy subjects and in those at considerable risk for coronary artery disease or with established coronary artery disease.
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