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In randomized clinical paleo trials that enrolled patients with pre-existing coronary heart disease, omega-3 fatty acid supplements significantly reduced cardiovascular events (deaths, non-fatal heart attacks, and non-fatal strokes). Omega-3 fatty acids reduce the risk for cardiovascular disease through a number of paleo mechanisms, including paleo a reduction in heart beat irregularities called arrhythmias, a decrease in blood clots which in turn can decrease the risk for heart attack and stroke, decrease in blood triglycerides, slightly lower blood pressure, decrease rate of plaque formation in arteries, reduce overall inflammation which is now known to be an important factor causing atherosclerosis. In addition to reducing the risk for heart disease, regular consumption of fish or supplemental omega-3 fatty acids may be helpful in preventing, treating, or improving a wide variety of diseases and disorders, including but not limited to virtually all inflammatory diseases (any disease ending with "itis"), rheumatoid arthritis, inflammatory bowel disorders (Crohn's disease, ulcerative colitis), periodontal disease (gingivitis), mental disorders (autism, depression, postpartum depression,
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