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Studies comparing measures of immune cell function outside the body (ex vivo) at baseline and after supplementing people with omega-3 fatty acid base balance acids, mainly EPA and DHA, have demonstrated immunosuppressive effects acid base balance at doses as low as 0.9 g/day for EPA and 0.6 g/day for DHA.1 Although it is not clear if these findings translate to impaired immune responses in vivo, caution should be observed when considering omega-3 fatty acid supplementation in individuals with compromised immune systems. Infant Formula In early studies of DHA-enriched infant formula, EPA- and acid base balance DHA-rich fish oil was used as a source of DHA. However, some preterm infants receiving fish oil-enriched formula had decreased plasma AA concentrations, which were associated with decreased growth.154 This effect was attributed to the potential for high concentrations of EPA to interfere with the synthesis of AA, which is essential for normal growth.
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