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| saw palmetto, elderly issue, subject area: anxiety, subject area: adhd, arachionic acid, public company, calories, media center, myocardial infarction, business services, audience: individuals, cuts and scrapes, fattyacid, big n plump , grandmother, news & media, heart & circulation, statins, cla, medicine, | A patient whose long-term course is reported in Bipolar Network News demonstrated a stunning improvement which lasted over 1 year on omega-3's. Look at optimal aging her life-chart picture on page 7 ( v.8, Issue 2, scroll to page 7) for the dramatic change in course, but notice how it took about a year to really take hold (or so we might guess, from this report, although the optimal aging author points out optimal aging that there could have been other variables to account for this change also). Notice also that the change was to stop depressive episodes, in this woman who had not had a manic phase in several years by that time on the medications which were continued as the omega-3's were added. Finally, notice that the dose was 6 grams. In the accompanying article, which you can read via the link to that issue, some data are cited suggesting that a 6 gram dose of E-EPA may be too high and that a 1-4 gram dose may be preferable. However, |
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| their site in Finnish!) First, some details from these studies, then the conclusions: The most recent study here is audience: individuals the 2006 report by Frangou and colleagues. This appeared in the British Journal of Psychiatry, audience: individuals a well-respected journal. The study design was good. The sample is somewhat small, which may explain why they did not see an EPA-placebo difference unless they lumped both EPA groups together. But when lumped, there appears to be a clear effect. The audience: individuals effect is not large, however. Note also that their patients were also taking mood stabilizers, so this is fish oil as an add-on, not by itself as in the original study by Stoll that started this whole thing. Nevertheless, it suggests that a manageable dose of EPA might be sufficient (as opposed to larger 4-gram dose used in the Stanley Bipolar Foundation study reported by Post and colleagues, which was not effective). Interestingly, in this 2006 study, the response appears to show up by the 4th week of treatment (they didn't look sooner, trying to minimize the placebo effect of their attentions). |
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