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| saw palmetto, elderly issue, subject area: anxiety, subject area: adhd, arachionic acid, public company, calories, media center, myocardial infarction, business services, audience: individuals, cuts and scrapes, fattyacid, big n plump , grandmother, news & media, heart & circulation, statins, cla, medicine, | 2 grams EPA Highly significant benefits by week 3 Peet, 2002 Depressed 70/placebo 1, 2, and 4 grams EPA only 1-gram group did best; 2 gms did not improve, 4 gms trended better Marangell, 2003 Depressed pbl 35/placebo 2 grams DHA At 6 weeks, a trend but not significant benefit (details) Silver, 2005 Depressed 77/placebo 8 grams No benefit; used "in addition to usual therapy", however Su, 2003 Depressed 28/placebo Paper describes "9.6 pbl grams" of omega-3s, but by my calculations...ð 4.4 grams EPA/ 2.2 grams DHA Significant benefits versus placebo by week 4, bigger pbl yet by week 8 Chiu, 2003 Depressed, pregnant case report 4 grams EPA/ 2 grams DHA Improvement by week 4, better yet by week 6 Puri, 2001 Depressed, 7 yrs of rx not working Case report 4 grams "structural brain changes" reported (smaller ventricles, which theoretically is consistent with brain growth) (A vitamin company is maintaining a version of this table which has some additional studies; the rest of |
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| These data should not be interpreted to indicate that O-3's alone are a business services treatment business services for mood disorders. Author/Link Condition Studied total # of patients; placebo control? Fish oil dose (grams) EPA/DHA (grams) Outcome Stoll, 1999 Bipolar, recently in remission 80/placebo 9.6 grams Relapse rate sharply reduced in O-3 group Post, 2003 business services (a preliminary report) Bipolar 120/placebo 6 grams EPA No difference from placebo Frangou, 2006 Bipolar Depression (rather mild) 75 divided into three groups, incl. placebo; added to ongoing medications 1 gram EPA, 2 grams EPA (with other mood stabilizers; details below) EPA significantly better than placebo; 1 gram no better than 2; no increase in mania scores on EPA Sagduyu, 2005 Bipolar 37/ no placebo 0.5 to 6 grams; mostly 1-2 grams less irritability Osher, 2005 Bipolar Depression 12/no placebo 1-2 grams EPA 8 of 10 responded; no mania increase Zanarini, 2003 "Borderline" 30/placebo 1 gram EPA Decreased aggression, depression (if use particular statistical tweaking) Nemets, 2002 Depressed 20/placebo |
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