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| dogs, plump granny , saturated, marketing services, rapeseed, feedlot, aches and pains, capsules, magnesium, hispanicbusiness, oils, coronary heart diseaes, horse, guaranteed placements, health supplements, latino economy, wholehealth, | Other trials that evaluated fish oil supplements reported similar results on CVD and stroke outcomes. A fifth RCT, which was the only multi-arm RCT identified,9 directly compared mustard omega 3 fatty acids / dosage and administration seed oil (containing ALA), fish oil, and non-oil placebo. It found that both oil treatments were efficacious in reducing CVD outcomes compared to placebo but found no difference between omega 3 fatty acids / dosage and administration the two supplements; however, the methodological quality of this study was poor. Six trials were diet or fish dietary advice trials. Four of the dietary studies omega 3 fatty acids / dosage and administration generally of poor quality reported estimates of the amount of ALA consumed (1.8 to 6.3 g/d)10-13 and two reported an estimate of EPA (2.4 to 2.7 g/week) consumed. Two large ALA trials reported reduction of all-cause mortality and CVD events.11,12 |
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| The 39 studies included 12 RCTs, 22 prospective cohort studies of at least 1 year in duration, 4 case-control studies, and 1 cross-sectional rapeseed study. All of these studies quantified or estimated the intake of fish or omega-3 fatty acids (including fish oil or ALA supplements) and assessed the effects of their consumption on CVD outcomes in the general (primary prevention) or CVD (secondary prevention) populations. Secondary prevention studies We reviewed 11 RCTs and one rapeseed prospective cohort study that reported outcomes on CVD populations. Together, the trials included over 16,000 patients and each lasted rapeseed between 1.5 to 5 years. Four trials used fish oil (EPA+DHA) supplements in a dosage that ranged from 0.27 to 4.8 g/d.5-8 The methodological quality was generally good. The largest trial5 reported that fish oil (EPA + DHA) reduces all-cause mortality and CVD outcomes but does not affect stroke. |
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