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| dogs, plump granny , saturated, marketing services, rapeseed, feedlot, aches and pains, capsules, magnesium, hispanicbusiness, oils, coronary heart diseaes, horse, guaranteed placements, health supplements, latino economy, wholehealth, | This trial contributed about one-third of the total number of gastrointestinal complaints (in both the omega-3 fatty acid arm and the control arm) from all the studies combined, and also contributed almost all the withdrawals due to adverse events (although the reasons for withdrawals were not given). This discordance suggests that news release distribution most other studies did not adequately report adverse event data, especially concerning withdrawals. None of the serious adverse events that were reported news release distribution associated omega-3 fatty acid news release distribution consumption with events such as death, life-threatening illness, or significant disability or handicap, although two studies reported that some important bleeding occurred with fish oil combined with aspirin or warfarin.39,40 Return to Contents Discussion Overall, a number of studies offer evidence to support the hypothesis that fish, fish oil, or ALA supplement consumption reduces all-cause mortality and various CVD outcomes, although the evidence is strongest for fish or fish oil. |
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| Similarly, none of the cohort studies specifically adjusted for CVD risk factor medications. Adverse Events Associated With Omega-3 Fatty Acid Consumption We reviewed 395 human clinical articles for reports of adverse events associated with omega-3 fatty acid consumption. We rejected 247 articles because they did not provide adverse event information and two additional articles that health supplements were duplicate publications. Of the remaining 148 articles in the general and CVD populations, a variety of adverse events were reported in 71 studies, but 77 RCTs and non-randomized health supplements comparison studies reported no adverse events. One hundred and forty-two articles provided data on about health supplements 20,000 subjects, about one-half of whom were exposed to different forms and dosages of omega-3 fatty acid for durations ranging from 1 to 364 weeks. The majority of the studies evaluated a few dozen subjects for less than 6 months. The GISSI-Prevention trial, that had over 11,000 subjects and a followup duration of 182 weeks, reported the largest number of adverse events.5 |
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