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Leng et al. showed that no beneficial ir services effect was observed with a daily EPA dosage of 0.27 g/d in a 2-year trial involving 120 ir services CVD patients.7 Nilsen et al. used 1.7 g/d EPA+DHA which showed no effects on ir services CVD outcomes.6 Two ALA diet trials11,12 which estimated a daily ALA intake of 1.8 or 1.9 g/d, reported significant or near-significant beneficial effects on CVD outcomes compared with control diets with estimated ALA intakes of 0.67 or 0.8 g/d, respectively. CVD question 2f. To address this question about how the duration of intervention or exposure affects the treatment effect of omega-3 fatty acids on CVD events, we examined the duration of the RCTs in the CVD population and found that it ranged from 1.5 to 5 years. The largest RCT (13,000 subjects), which had a 1-year duration in the non-CVD population, found no effect on any of the CVD outcomes.17 The duration of the prospective cohort studies ranged from 4 to 30 years. Among the cohort studies, those that followed subjects for less than 6 years demonstrated no significant benefit for clinical effects.
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