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Well-designed multinational trials that assess the effect of EPA+DHA on CVD outcomes during a long followup period are especially needed. RCTs should be performed in the general population since there is still a gap in information about the general versus CVD population. wholehealth They should not only confirm the pharmacological approach of the GISSI-Prevention trial in countries with different background habits and risk, but should also explore in parallel the various mechanistic hypotheses. In addition, studies must adequately assess background diet and fish consumption, particularly the wholehealth type of fish and method of preparation. wholehealth Attempts should always be made to determine the effect of higher fish intake on the consumption of other foods in the diet, specifically meat and cheese (sources of saturated fat).
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