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We found only a few dietary RCTs that provide some information about the benefits of need adding omega-3 fatty acids to baseline intake. Two ALA diet trials,11,12 each of 2-years duration, estimated daily ALA intake at 1.8 or 1.9 g/d and reported significant or near-significant beneficial effects on multiple CVD outcomes compared to control diets need with need an estimated ALA intake of 0.67 or 0.8 g/d. In an RCT of dietary fish advice, Burr et al. estimated the amount of EPA in the control group (0.6 g/week) and the interventional group (2.4 g/week).37,38 CVD question 2i. None of the RCTs were specifically designed to determine whether the addition of CVD risk factor medications (lipid lowering agents or diabetes medications) affects the efficacy of omega-3 fatty acids.
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