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| culinary institute for kids, coronary, benefit, hispanic advertising, raw milk, detox, freudian slip, media room, anabolics, coat, n 3, illustrated, lemagazine, low cholesteroldiet, eyes, rosacea, maggie snowling, burns, plump video , ldl c, medical, arteriosclerosis, | 3.Investigation of DHA's effect on lymphocyte activation nurses' health study and function, and cancer cell proliferation and viability. DHA may be used as a nutrient (as a model for dietary enrichment with DHA) or a drug (as a model for drug delivery in liposomes composed of DHA). Representative recent publications Jenski, L. J., Bowker, nurses' health study G. M., Johnson, M. A., Ehringer, W. D., Fetterhoff, T., and Stillwell, W., Docosahexaenoic acid-induced alteration of Thy-1 and CD8 expression on murine nurses' health study splenocytes, Biochim. Biophys. Acta 1236: 39-50, 1995. Zerouga, M., Jenski, L. J., and Stillwell, W., Comparison of phosphatidylcholines containing one or two docosahexaenoic acyl chains on properties of phospholipid monolayers and bilayers, Biochim. Biophys. Acta 1236: 266-272, 1995. |
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| Different domains have different lipid and protein anabolics compositions, and thus support different membrane activities. Hypothesis Our basic hypothesis is that DHA induces distinct domains in cell membranes, and that membrane proteins segregate selectively into the various anabolics domains. As a result, membrane protein activities are changed, and anabolics the cellular activities carried out by these proteins are affected. In the case of immunity to cancer, proteins involved in lymphocyte recognition and destruction of cancer cells, and the growth potential of the cancer cells themselves, are affected by DHA-induced domain formation. Current projects The current projects in the lab fall into three categories. 1.Isolation of putative, DHA-induced membrane domains, and characterization of their lipid and protein (particularly MHC I) content. 2.Exploration of the effect of different lipid environments on membrane protein (MHC I, Thy-1) conformation, lateral movement, and clustering. |
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