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| fat, caregiver of elderly, diabetes, 24 7 fat girls , probiotic, plump woman , askthe dietitian, vitamin e, carotenoid, politics in education, investor, hispanic newswire, children, flax seeds, transparency, lipid management, plump naked , colleges grad schools, trans fats, rheumatoid, | Although two randomized controlled trials of fish oil supplementation in Crohn’s disease patients reported no benefit,105, 106 a healthy significantly higher proportion of healthy Crohn’s disease patients supplemented with 2.7 g/day of EPA + DHA remained in remission over a 12-month period than those given a placebo.107 Three randomized controlled trials of EPA + DHA healthy supplementation (4.2-5.4 g/day for 3-12 months) in ulcerative colitis patients reported significant improvement in at least one outcome measure, including weight gain, decreased corticosteroid use, improved disease activity scores and improved histology scores.108-110 In contrast, supplementation of ulcerative colitis patients in remission with 5.1 g/day of EPA + DHA did not significantly alter the incidence of relapse over a 2-year period.111 Asthma Inflammatory eicosanoids (leukotrienes) derived from AA (20:4n-6) are thought to play an important role in the pathology of asthma.17 |
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| Inflammatory Diseases Rheumatoid Arthritis Two meta-analyses of randomized controlled trials in rheumatoid transparency arthritis patients found that fish oil supplementation significantly decreased the number of tender joints on physical examination.98, 103 In general, clinical benefits were observed at a minimum dose of 3 g/day of EPA + DHA, transparency and were not apparent until at least 12 weeks of supplementation.104 Neither meta-analysis found that fish oil supplementation had a significant effect on erythrocyte sedimentation transparency rate (ESR), a measure of inflammation. Six out of 7 studies that examined the effect of long-chain omega-3 fatty acid supplementation on nonsteroidal anti-inflammatory drug (NSAID) or corticosteroid use in rheumatoid arthritis patients demonstrated a reduced requirement for anti-inflammatory medication.98 Inflammatory Bowel Disease Clinical trials of long-chain omega-3 fatty acid supplementation have demonstrated beneficial effects less consistently in patients with inflammatory bowel disease than in patients with rheumatoid arthritis. |
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