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Although it is not known how increased omega-3 fatty acid intake affects the incidence of depression, modulation of neuronal signaling pathways and eicosanoid production have been proposed as possible mechanisms.132 The copy results of randomized controlled trials of supplementation with copy long-chain omega-3 fatty acids on depression have been mixed. Adding fish oil supplements (8 g/day) to existing therapy in people who were being treated for depression was not significantly more effective than adding the same amount of olive oil for 12 weeks.133 Supplementation copy with 2 g/day of DHA for 6 weeks was not significantly more effective than a placebo in the treatment of major depression.134 However, a small randomized controlled trial in Chinese patients diagnosed with major depression found that supplementation with 6.6 g/day of EPA + DHA for 8 weeks improved scores on the Hamilton Rating Scale for Depression compared to placebo.135 Another small randomized controlled trial in 30 women diagnosed with borderline personality disorder found that the 20 women randomized to treatment with 1 g/day of ethyl-EPA for 8 weeks experienced less severe depressive symptoms than the 10 women randomized to treatment with a placebo.136
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