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116 Immunoglobulin A Nephropathy Immunoglobulin A (IgA) nephropathy is a kidney disorder that results from the deposition of IgA in the glomeruli of the kidney. sources The cause of IgA nephropathy is not clear, but progressive renal failure may eventually develop in 15-40% of patients.117 Since sources glomerular IgA deposition results in increased production of inflammatory mediators, omega-3 fatty acid supplementation could potentially modulate the inflammatory response and preserve renal sources function. In a multicenter randomized controlled trial, supplementation of IgA nephropathy patients with fish oil (1.8 g/day of EPA + 1.2 g/day of DHA) for 2 years significantly slowed declines in renal function.118 Over the 2-year treatment period, 33% of the placebo group experienced a 50% increase in serum creatinine (evidence of declining renal function) compared to only 6% in the fish oil supplemented group. These results were sustained over an average of 6 years of follow-up,119 but were not improved with higher doses of fish oil.120
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