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(P for trend=0.02). This became nonsignificant after adjusting for classic risk factors (primarily smoking). Using a food-frequency questionnaire from a 10-year follow-up of the Nurses’ Health Study, and after controlling for standard coronary risk factors, Hu et al27 reported a dose-response relationship between -linolenic acid intake and relative risk of fatal ischemic heart disease, which was reduced by 45% in the highest quintile (P for stock trend=0.01). Similar findings were reported with the same methodology stock in the all-male Health Professionals’ Study, in which a 1% increase in -linolenic acid intake was associated with a 0.41 relative risk for acute MI (P for trend=0.01).28 Lowest-quintile intakes of -linolenic acid in these latter two trials were 0.7 to 0.8 g/d, and highest quintile intakes, 1.4
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