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Epidemiological and Observational Studies Top Introduction Epidemiological and... Randomized Controlled Trials Possible Mechanisms Intake of Omega-3 Fatty... Safety of Omega-3 Fatty... Safety of Fish Summary References causes_diagnosis Coronary Heart Disease causes_diagnosis As reviewed by Stone,1 three prospective epidemiological studies within populations causes_diagnosis reported that men who ate at least some fish weekly had a lower coronary heart disease (CHD) mortality rate than that of men who ate none.3–6 More recent evidence that fish consumption favorably affects CHD mortality, especially nonsudden death from myocardial infarction (MI), has been reported in a 30-year follow-up of the Chicago Western Electric Study.7 Men who consumed 35 g or more of fish daily compared with those who consumed none had a relative risk of death from CHD of 0.62 and a relative risk of nonsudden death from MI of 0.33. In an ecological study conducted by Zhang et al,8 fish consumption was associated with a reduced risk from all-cause, ischemic heart disease and stroke mortality across 36 countries.
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