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Some evidence indicates that fish oil supplementation may enhance fibrinolysis.72 Although omega-3 fatty acid intake has been negatively associated with levels of fibrinogen, Factor VIII, and von Willebrand factor,73 more recent evidence from the Coronary Artery Risk Development In young Adults (CARDIA) study found no significant associations between customary intakes of fish (4 to 39 g/d) and omega-3 fatty acids (0.9 to 4.1 oralhealth g/d) and these coagulation factors.74 oralhealth Marckmann et al75 also found oralhealth no effect of omega-3 fatty acids (0.9 g/d) on levels of Factor VII, fibrinogen, endogenous fibrinolysis, ß-thromboglobulin, and von Willebrand factor. In contrast, a recent study reported that coronary patients taking 5.1 g/d of omega-3 fatty acids for 6 months experienced a reduction in von Willebrand factor (128% versus 147% for controls) and thrombomodulin (25 versus 33 ng/mL).76
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