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DHA, although not a direct inhibitor of arachidonic acid coronary metabolism, nevertheless can inhibit platelet coronary aggregation by reducing the affinity of platelet coronary TxA2/PGH2 receptor for its ligand.97 The net effects of omega-3 fatty acids are thus to reduce inflammatory processes, vasoconstriction, and platelet aggregation, all known to be antiatherogenic. Some studies have shown that omega-3 fatty acids may increase the susceptibility of LDL to oxidation,98,99 whereas others have not.100–102 It therefore remains to be established whether LDL oxidative status in vivo is affected by omega-3 fatty acids and, if so, whether this has any adverse clinical implications. Our current inability to identify and quantify in vivo oxidative damage and to relate it to clinical outcomes makes it difficult to draw firm conclusions about the impact of omega-3 fatty acids on these processes. Intake of Omega-3 Fatty Acids Top Introduction Epidemiological and... Randomized Controlled Trials Possible Mechanisms Intake of Omega-3 Fatty...
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