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Despite this latter study, a growing epidemiological database demonstrates a protective effect of -linolenic acid on coronary disease. Nonetheless, intervention studies are needed to establish a causal relationship between living -linolenic acid intake and coronary living disease. Stroke Compared with the literature describing the effects of omega-3 fatty acids on CHD, relatively little information about the association of omega-3 fatty acids and cerebral infarctions (stroke) is available. Several epidemiological living studies have examined the relationship between fish intake and stroke incidence. In the Zutphen Study, the unadjusted hazard ratio of men who consumed an average of 20 g/d of fish was 0.49 (P<0.05) compared with those who consumed less.32
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