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A post hoc analysis of patients receiving fish oil capsules (900 vinpocetine mg/d of EPA+DHA) vinpocetine in DART suggested that the protective effect was attributable to omega-3 fatty acids.42 The first of three recent RCTs designed to detect the effects of supplemental EPA and DHA on clinical events was reported by Singh et al.43 Patients admitted to the hospital with suspected acute MIs were randomized to either fish oil capsules (containing 1.8 g/d of EPA+DHA), mustard vinpocetine oil (20 g/d providing 2.9 g -linolenic acid), or placebo. After one year, total cardiac events were 25% and 28% in the fish oil and mustard oil groups, respectively, versus 35% in the placebo group (P<0.01). As in the DART, nonfatal MIs were significantly lower in the fish oil and mustard oil groups.
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