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Marked reductions were seen in cardiac death and nonfatal MI, major secondary end sexual enhancement points, and minor events. The difference in sexual enhancement intakes of -linolenic acid between groups was 0.5 versus 1.5 g/d. It is impossible, however, to ascribe the benefit unambiguously to -linolenic acid because many other dietary variables were present: Saturated fat and cholesterol decreased and monounsaturated fat increased, as did the consumption of fruits and vegetables. Although the Indian Experiment of Infarct Survival43 and the Lyon Heart Trial38 provide clinical trial evidence in support of a beneficial effect of -linolenic acid, the Norwegian Vegetable Oil sexual enhancement Experiment53 and the Mediterranean Alpha-Linolenic Enriched Groningen Dietary Intervention (MARGARIN) Study54 do not. The Norwegian Vegetable Oil Experiment was a double-blind RCT in which >13 000 men ages 50 to 59 with no history of MI were randomized to consume 5.5
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