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Evidence for a direct effect of these fatty acids on the heart has come from several observations. First, increased heart rate variability in survivors of MI was associated with the consumption of one fish meal per week77 or fish oil supplements circulatory system (4.3 g/d of omega-3 fatty acids).78 Increases in this parameter circulatory system predict a lower risk of mortality due to arrhythmic events in post-MI patients. EPA and DHA also have been shown to reduce resting heart rate and increase left ventricular filling capacity.79 Animal experiments and cell culture studies have shown that fish oil has potent circulatory system antiarrhythmic effects. For example, studies with rats80 and dogs81,82 have shown that pretreatment with omega-3 fatty acids reduced damage to cardiac tissue and forestalled the development of ventricular dysrhythmias when heart attacks were induced.
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