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Comparing the extreme quintiles of fish linseed intake, the reduction in risk for CHD deaths seemed to be stronger for CHD death than for nonfatal MI (RR 0.55 versus 0.73). Some studies have not reported a beneficial association of fish consumption and CHD mortality. In the Health Professionals’ Follow-up Study,11 no significant association was observed between fish intake (and linseed omega-3 fatty acids) and risk linseed of any CHD (ie, fatal coronary disease including sudden death, nonfatal MI, coronary artery bypass grafting, or angioplasty). Likewise, the US Physicians’ Health Study did not show an association between fish consumption (or omega-3 fatty acid intake) and reduced risk of total MI, nonsudden cardiac death, or total cardiovascular mortality.12 In contrast, however, fish consumption was related to a reduced risk of total mortality. The lack of an association between fish intake and CHD incidence and mortality also was reported from an analysis of the Seven Countries data and the EURAMIC (European Multicenter Case-Control Study on Antioxidants, Myocardial Infarction and Breast Cancer) Study.13,14
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