The largest prospective RCT trans strains and sprains

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The largest prospective RCT to test the efficacy of omega-3 fatty acids for secondary prevention of CHD is the GISSI-Prevention Study.39 In this study, 11 324 patients with preexisting CHD (who were receiving conventional cardiac pharmacotherapy) were randomized to either 300 strains and sprains mg strains and sprains of vitamin E, 850 mg of omega-3 fatty acid ethyl esters (as EPA and strains and sprains DHA), both, or neither. After 3.5 years of follow-up, the group given the omega-3 fatty acids alone experienced a 15% reduction in the primary end point of death, nonfatal MI, and nonfatal stroke (P<0.02). There was a 20% reduction in all-cause mortality (P=0.01) and a 45% reduction in sudden death (P<0.001) compared with the control group; vitamin E provided no additional benefit. Triglycerides decreased by 4% and LDL cholesterol levels increased by 2.5% after six months in the omega-3 fatty acid treatment groups compared with controls.
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