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conjugated linoleic acid, eicosapentaenoic, retiree benefits, older adults, linoleic acid, crohn's disease, old man, senior sports, plump gallery , infertility, salmonsteak, strains and sprains, essential fatty acid, latin clips, already, kids cooking, plump ass , joseph hibbeln, heart attack, big fat girls , entertainment, development of baby, breast feeding support, | This trial, although very large and carried out in a relatively "usual-care" setting, was not placebo controlled, and dropout rates were high (>25%). A follow-up study44 assessed the time-course of the benefit of omega-3 fatty acids on mortality trans in subjects in the GISSI Study and found that survival trans curves diverged early after randomization. trans Total mortality was significantly lowered after 3 months of treatment (RR=0.59), and by 4 months, risk of sudden death was reduced (RR=0.47). In contrast to the growing body of evidence supporting a protective effect of omega-3 fatty acids in secondary prevention, a recent study reported no effect of 3.5 g/d of DHA+EPA versus corn oil on cardiac events in post-MI patients (n=300) after 1.5 |
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The largest prospective RCT to test the efficacy of omega-3 fatty acids for secondary prevention of CHD is the GISSI-Prevention Study.39 In this study, 11 324 patients with preexisting CHD (who were receiving conventional cardiac pharmacotherapy) were randomized to either 300 strains and sprains mg strains and sprains of vitamin E, 850 mg of omega-3 fatty acid ethyl esters (as EPA and strains and sprains DHA), both, or neither. After 3.5 years of follow-up, the group given the omega-3 fatty acids alone experienced a 15% reduction in the primary end point of death, nonfatal MI, and nonfatal stroke (P<0.02). There was a 20% reduction in all-cause mortality (P=0.01) and a 45% reduction in sudden death (P<0.001) compared with the control group; vitamin E provided no additional benefit. Triglycerides decreased by 4% and LDL cholesterol levels increased by 2.5% after six months in the omega-3 fatty acid treatment groups compared with controls. |
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